Lead PI: Jeffrey Shaman

Unit Affiliation: Mailman School of Public Health

January 2016 - December 2019
North America ; New York City, NY ; New York
Project Type: Research

DESCRIPTION: The Prometheus program aims to improve military readiness and force health through development of a prognostic that can determine if an individual is contagious before he exhibits symptoms of illness. DARPA’s goal is to develop a molecular test for determining if an individual is likely to spread disease following exposure to an infectious agent and predict within 24 hours of exposure if that individual will become contagious. That ability to predict contagiousness would allow for specific planning and concentration of resources to prevent the spread of an illness from an individual to a population within the confined settings and close quarters typical of military operations.

Prometheus specifically aims to discover a minimal set of biological signals in a person recently infected with disease that would indicate the potential for contagiousness, characterizing a person's genetic and molecular-level immune responses at multiple time points during the infection process. These temporal “biomarkers”—measurable indicators of the severity or presence of some disease state—might help researchers predict the onset of contagiousness earlier than is currently possible using conventional medical technology.